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Glucuronidation of drugs and other compounds

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Published by CRC Press in Boca Raton, Fla .
Written in English

Subjects:

  • Drugs -- Metabolism,
  • Glucuronic acid -- Synthesis,
  • Glucuronates -- Metabolism,
  • Drugs -- Metabolism

Book details:

Edition Notes

Includes bibliographical references and index.

StatementGeoffrey J. Dutton.
Classifications
LC ClassificationsRM301.55 .D87
The Physical Object
Pagination268 p. ;
Number of Pages268
ID Numbers
Open LibraryOL4114745M
ISBN 100849352959
LC Control Number80036895

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Additional Physical Format: Online version: Dutton, Geoffrey J. Glucuronidation of drugs and other compounds. Boca Raton, Fla.: CRC Press, © Get this from a library! Glucuronidation of drugs and other compounds. [G F Dutton] -- Published in In a previous publication on glucuronic acid both free and conjugated, the author expressed the hope that glucuronic acid studies over the following few years might expand   glucuronidation of drugs and other compounds By Jir? Akagawa FILE ID fa Freemium Media Library glucuronidation or glucuronosylation glucuronidation is a major phase ii    Contributor By: Eleanor Hibbert Public Library PDF ID b40e glucuronidation of drugs other compounds pdf Favorite eBook Reading substances it is the most important pathway for the human bodys elimination of the most frequently

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Glucuronidation, which involves the covalent addition of glucuronic acid to a chemical, is an elimination and detoxification mechanism for a host of lipophilic compounds that includes drugs, environmental chemicals, and endobiotics. In addition, since glucuronides are charged, this pathway facilitates the excretion of the parent compound in    glucuronidation of drugs and other compounds Posted By Anne GolonMedia TEXT ID b19d4 Online PDF Ebook Epub Library Glucuronidation Of Drugs And Other Compounds Routledge buy glucuronidation of drugs and other compounds routledge revivals read kindle store reviews amazoncom   Drugs and other foreign compounds that are acetylated in intact animals are either aromatic amines or hydrazines, which are converted to aromatic amides and aromatic hydrazides (Parkinson, ). Acetylation reactions are characterized by the transfer of an acetyl moiety, the donor generally being acetyl coenzyme A, while the accepting chemical   Substrate for other UGTs, but highest CL int observed with UGT1A6. c. Subsequent studies have excluded propofol glucuronidation by UGT1A3, 1A10 and 2B15, although propofol has been demonstrated to be a substrate for UGT1A8 (extrahepatic). d. Morphine 6-glucuronidation